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Syracuse University, College of Arts and Sciences

Chemistry Publications

Small Molecule Targeting of SHIP1 and SHIP2

by: John D. Chisholm

Kerr, W. G.; Pedicone, C.; Dormann, S. D.; Pacherille, A.; Chisholm, J. D. “Small Molecule Targeting of SHIP1 and SHIP2.” Biochem. Soc. Trans. 2020, 48, 291-300. DOI:10.1042/BST20190775.

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

by: John D. Chisholm

Pedicone, C., Fernandes, S., Dungan, O. M., Dormann, S. M., Viernes, D. R., Adhikari, A. A., Choi, L. B., De Jong, E., Chisholm, J.D. and Kerr, W.G. "Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis." J. Cell Sci. 2020, 133, jcs238030. DOI:10.1242/jcs.238030.

ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position- and amino acid-dependent manner.

by: Carlos A. Castañeda and Heidi Hehnly

Dao TP, Martyniak B, Canning AJ, Lei Y, Colicino EG, Cosgrove MS, Hehnly H, Castañeda CA*. (2019) ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position- and amino acid-dependent manner. Structure. 27: 937-951. DOI: 10.1016/j.str.2019.03.012.

Ester Formation via Symbiotic Activation Utilizing Trichloroacetimidate Electrophiles

by: John D. Chisholm

Mahajani, N. S.; Meador, R. I. L.; Smith, T. J.; Canarelli, S. E.; Adhikari, A. A.; Shah, J. P.; Russo, C. M.; Wallach, D. R.; Howard, K. T.; Millimaci, A. M.; Chisholm, J. D. “Ester Formation via Symbiotic Activation Utilizing Trichloroacetimidate Electrophiles” J. Org. Chem. 2019, 84, 7871-7882. DOI:10.1021/acs.joc.9b00745

Friedel-Crafts Alkylation of Indoles with Trichloroacetimidates.

by: John D. Chisholm

Suzuki, T.; Chisholm, J. D. "Friedel-Crafts Alkylation of Indoles with Trichloroacetimidates." Tetrahedron Lett., 2019, 60, 1325-1329. DOI:10.1016/j.tetlet.2019.04.007

Dialkylation of Indoles with Trichloroacetimidates to access 3,3-Disubstituted Indolenines

by: John D. Chisholm

Suzuki, T.; Mate, N. A.; Adhikari, A. A.; Chisholm, J. D. "Dialkylation of Indoles with Trichloroacetimidates to access 3,3-Disubstituted Indolenines." Molecules 2019, 23, 4143-4158. DOI:10.3390/molecules24224143

Single amino acid substitutions in stickers, but not spacers, substantially alter UBQLN2 phase transitions and dense phase material properties.

by: Carlos A. Castañeda

Yiran Y, Jones HB, Dao TP, Castañeda CA*. (2019) Single amino acid substitutions in stickers, but not spacers, substantially alter UBQLN2 phase transitions and dense phase material properties. Journal of Physical Chemistry B. 123: 3618-3629. DOI: 10.1021/acs.jpcb.9b01024.

Cover of ChemCatChem journal

Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

by: Ivan V. Korendovych and Carlos A. Castañeda and Olga Makhlynets

Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity, (ChemCatChem 5/2019), Dr. Elizabeth A. Caselle, Jennifer H. Yoon, Sagar Bhattacharya, Joel J. L. Rempillo , Zsófia Lengyel, Dr. Areetha D'Souza, Dr. Yurii S. Moroz, Patricia L. Tolbert, Dr. Alexander N. Volkov, Prof. Dr. Marcello Forconi, Prof. Dr. Carlos A. Castañeda, Prof. Dr. Olga V. Makhlynets, Prof. Dr. Ivan V. Korendovych, https://doi.org/10.1002/cctc.201900266

Promoter Free Allylation of Trichloroacetimidates with Allyltributylstannane Under Thermal Conditions to Access the Common 1,1’-Diarylbutyl Pharmacophore

by: John D. Chisholm

Mahajani, N. S.; Chisholm, J. D. "Promoter Free Allylation of Trichloroacetimidates with Allyltributylstannane Under Thermal Conditions to Access the Common 1,1’-Diarylbutyl Pharmacophore." Org. Biomol. Chem. 2018, 16, 4008-4012. DOI:10.1039/C8OB00687c

Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions.

by: Carlos A. Castañeda and Heidi Hehnly

Dao TP, Kolaitis R-M, Kim HJ, O’Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA*. (2018) Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions. Molecular Cell. 69: 965-978. DOI: 10.1016/j.molcel.2018.02.004.

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

by: Robert Doyle and George M. Langford and Torsten Wöllert

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG. Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors. Scientific Reports. 2018; 8(1):3749.

A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents

by: Robert Doyle

Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, Reiner DJ, Koch-Laskowski K, McGrath LE, Lhamo R, Stein LM, De Jonghe BC, Holz GG, Roth CL, Doyle RP, Hayes MR. A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents. Diabetes, obesity & metabolism, 2018, 20, 1223-1234.

Exploring the Multi-ligand Binding Specificity of Saposin B Reveals Two Binding Sites.

by: Robert Doyle

Tinklepaugh J, Smith BM, Hanlon E, Zubieta C, Bou-Abdallah F, Doyle RP. Exploring the Multi-ligand Binding Specificity of Saposin B Reveals Two Binding Sites. ACS Omega. 2017; 2(10):7141-7145.

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival

by: John D. Chisholm

Gumbleton, M.; Sudan, R.; Fernandes, S.; Engelman, R. W.; Russo, C. M.; Chisholm, J. D.; Kerr, W. G. "Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival." Sci. Signal. 2017, 10, eaam5353. DOI:10.1126/scisignal.aam5353

89Zr-Cobalamin PET Tracer: Synthesis, Cellular Uptake, and Use for Tumor Imaging.

by: Robert Doyle

Kuda-Wedagedara ANW, Workinger JL, Nexo E, Doyle RP, Viola-Villegas N. 89Zr-Cobalamin PET Tracer: Synthesis, Cellular Uptake, and Use for Tumor Imaging. ACS Omega. 2017; 2(10):6314-6320.

Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation

by: Robert Doyle

Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation Doyle RP, Moody K, Nie Y, Bou-Abdallah F, Tinklepaugh J, Smith BM, Grown K. ChemPhotoChem. 2017, 1(6):256.

Lewis Acid Catalyzed Displacement of Trichloroacetimidates in the Synthesis of Functionalized Pyrroloindolines

by: John D. Chisholm

Adhikari, A. A.; Chisholm, J. D. "Lewis Acid Catalyzed Displacement of Trichloroacetimidates in the Synthesis of Functionalized Pyrroloindolines." Org. Lett. 2016, 18, 4100-4103. DOI:10.1021/acs.orglett.6b02024

Linkage-specific conformational ensembles of non-canonical polyubiquitin chains.

by: Carlos A. Castañeda

Castañeda CA*, Chaturvedi A, Camara CM, Curtis JE, Krueger S, Fushman D. (2016) Linkage-specific conformational ensembles of non-canonical polyubiquitin chains. Phys Chem Chem Phys 18: 5771-5788. DOI: 0.1039/C5CP04601G.

Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme.

by: Carlos A. Castañeda

Castañeda CA, Liu J, Chaturvedi A, Nowicka U, Cropp TA, Fushman D. (2011) Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme. J. Am. Chem. Soc. 133: 17855-17868. DOI: 10.1021/ja207220g.