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Eleanor Maine

Eleanor Maine

Department of Biology

346 Life Sciences Complex

Research and Teaching Interests

Genetic regulation of development, cell-signaling, germline development, RNA silencing.


  • Postdoctoral Fellow, University of Wisconsin-Madison (1986-1990)
  • Postdoctoral Fellow, Princeton University (1984-1986)
  • Ph.D., Princeton University (1984)


  • BIO 305: Integrated Biology Laboratory
  • BIO 503: Developmental Biology
  • BIO 700: Animal Developmental Mechanisms

Selected Publications

  • Yang, B. , X. Xu, L. Russell, M.T. Sullenberger, J.L. Yanowitz, and E.M. Maine (2019) A DNA repair protein and histone methyltransferase interact to promote genome stability in C. elegansPLoS Genetics 15(2):e1007992.  doi: 10.1371/journal.pgen.1007992.
  • Li, Y., and E.M. Maine (2018) The balance of poly(U) polymerase activity ensures germline identity, survival, and development in Caenorhabditis elegansDevelopment 145: dev165944.  doi: 10.1242/dev.165944.
  • Mutlu, B., H-M. Chen, J.J. Moresco, B.D. Orelo, B. Yang, J. Gaspar, S. Keppler-Ross, J.R. Yates III, D.H. Hall, E.M. Maine, and S.E. Mango (2018) Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos. Science Advances 4: eaat6224.
  • Safdar, K., A. Gu, X. Xu, V. Au, J. Taylor, S. Flibotte, D. G. Moerman, and E. M. Maine (2016) UBR-5, a conserved HECT-type E3 ubiquitin ligase, negatively regulates Notch-type signaling in C. elegans.  G3 6:2125-2134.
  • Guo, Y., B. Yang, Y Li, X. Xu, and E. M. Maine (2015) Enrichment of H3K9me2 on unsynapsed chromatin in Caenorhabditis elegans does not target de novo sites.  G3 5:1865-1878.
  • Van Wynsberghe, P. M., and E. M. Maine (2013) Epigenetic control of germline development. Advances in Experimental Medicine and Biology 757:373-403. Editor: T. Schedl. Publisher: Springer Verlag.
  • Fox, P.M., V.E. Vought, M. Hanazawa, M-H. Lee, E. M. Maine, and T. Schedl (2011) Cyclin E/CDK-2 regulates proliferative cell fate and cell cycle progression in the C. elegans germline. Development 138, 2223-2234.
  • Maine, E.M. (2010) Meiotic silencing in Caenorhabditis elegans. International Review of Cell and Molecular Biology 282, 91-134.
  • She, X., X. Xu, A. Fedotov, W.G. Kelly, and E.M. Maine (2009) Regulation of heterochromatin assembly during C. elegans meiosis by components of a small RNA-mediated pathway. PLoS Genet 5(8): e1000624. doi:10.1371/journal.pgen.1000624
  • Maine, E.M. (2008) Studying gene function in Caenorhabditis elegans using RNA-mediated interference. Briefings in Functional Genomics and Proteomics 7, 184-194.
  • Liu, Y., and E.M. Maine (2007) The Bro1-domain protein, EGO-2, promotes notch signaling in Caenorhabditis elegans. Genetics 177, 2265-2277.

    * This paper was featured in the Genetics Society of America Newsletter.
  • Maine, E. M., J. Hauth, T. Ratliff, V.E. Vought, X. She, and W. G. Kelly (2005) EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired DNA during C. elegans meiosis. Current Biology 15, 1972-1978.

    * This paper was cited by the Faculty of 1000.
  • Smardon, A., J. M. Spoerke, S. C. Stacey, M. E. Klein, N. Mackin, and E. M. Maine (2000) EGO-1 is related to RNA-directed RNA polymerase and functions in germline development and RNA interference in C. elegans. Current Biology 10, 169-178.

    * This paper was featured in Science Editor's Choice and Current Biology Dispatch reviews.