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Katharine (Kate) Lewis

Katharine (Kate) Lewis


Professor
Department of Biology

kelewi02@syr.edu

262 Life Sciences Complex
315.443.5902


Research Interests

Specification and patterning of spinal cord interneurons; Formation of functional neuronal circuitry; Evolution of spinal cord patterning and function; Dorsal-ventral neural tube patterning; zebrafish development.

Education

  • Postdoc, University of Oregon (1999-2003)
  • Ph.D., University College London (1994-1998)
  • Kennedy Memorial Scholar, Harvard University (1993-1994)
  • B.A. (Honors), Cambridge University (1990-1993)

Previous Academic Positions

Royal Society University Research Fellow, University of Cambridge 2004-2010

Selected Publications

R. Wilk, N. Ali, S. J. England, K. E. Lewis (2018) Using Zebrafish to Bring Hands-On Laboratory Experiences to Urban Classrooms. Zebrafish 15: 2 https://doi.org/10.1089/zeb.2017.1503

Andrzejczuk LA, Banerjee S, England SJ, Voufo C, Kamara K and Lewis KE (2018) Tal1, Gata2a, and Gata3 Have Distinct Functions in the Development of V2b and Cerebrospinal Fluid-Contacting KA Spinal Neurons. Front. Neurosci. 12:170. doi: 10.3389/fnins.2018.00170

J. L. Juárez-Morales, R. I. Martinez-De Luna, M. E. Zuber, A. Roberts and K. E. Lewis (2017) Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons. Devel. Neurobio. DOI: 10.1002/dneu.22490

S. England, P. Campbell, S. Banerjee, A. Swanson, K. E. Lewis (2017) Identification and expression analysis of the complete family of zebrafish pkd genes.Frontiers in Cell and Developmental Biology 5:5 doi: 10.3389/fcell.2017.00005

G.M.W Cook., K. E. Lewis, R. J. Keynes (2017) Neural Patterning: Spinal Cord Segmentation and Somite Patterning. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier. ISBN 9780128093245

W. C. Hilinski; J. R. Bostrom; S. J. England; J. L. Juárez-Morales; S. de Jager; O. Armant; J. Legradi; U. Strähle; B. A. Link; K. E. Lewis (2016) Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Development. 11:16 doi: 10.1186/s13064-016-0059-9

J. L. Juarez-Morales, C. Schulte, S. A. Pezoa, G. K. Vallejo, W. Hilinski, S. England, S. de Jager and K. E. Lewis (2016) Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2 independent mechanism. Neural Development. 11: 5 doi:  10.1186/s13064-016-0059-9

A.Thélie, S. Desiderio, J. Hanotel, I. Quigley, B. Van Driessche, A. Rodari, M. D. Borromeo, S. Kricha, F. Lahaye, J. Croce, G. Cerda-Moya, J. O. Fernandez, B. Bolle, K. E. Lewis, M. Sander, A. Pierani, M. Schubert, J. E. Johnson, C. R. Kintner, T. Pieler, C. Van Lint, K. A. Henningfeld, E. J. Bellefroid, and C. V. Campenhout (2015) Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Development:142:3416-3428 

S. England, Hilinski, W., de Jager, S., Andrzejczuk, L. , Campbell, P., Chowdhury, T. , Demby, C. , Fancher, W. , Gong, Y. , Lin, C. , Machikas, A., Rodriguez-Larrain, G. , Roman Rivera, V. and Lewis, K. E. (2014) Identifying Transcription Factors expressed by Ventral Spinal Cord Interneurons. ZFIN on-line publication. http://zfin.org/ZDB-PUB-140822-10.

S. England, M. F. Batista, J. K. Mich, J. K. Chen and K. E. Lewis (2011) Roles of Hedgehog Pathway Components and Retinoic Acid Signalling in Specifying Zebrafish Ventral Spinal Cord Neurons. Development 138: 5121-5134.  

D. K Goode, H. A. Callaway, G. A. Cerda, K. E. Lewis, and G. Elgar (2011) Minor change, major difference: divergent functions of highly conserved cis-regulatory elements subsequent to whole genome duplication events. Development 138: 879-884.

C. J. Schulte, C. Allen, S. England, J. Juárez-Morales, K. E. Lewis (2011) Evx1 is required for joint formation in zebrafish fin dermoskeleton. Developmental Dynamics 240: 1240-1248.

K. Wotton, F. Weierud J. L. Juarez Morales, L. E. Alvares, S. Dietrich, K. E Lewis (2010) Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. Development, Genes and Evolution 219:481-496

M. Hargrave, G. Cerda-Moya, K.E. Lewis (2009) RNA-profiling a specific class of zebrafish interneurons. Dev. Dyn. 238(1):150-161

G. Cooke, K.E. Lewis and R. Keynes (2009) Segmentation: Spinal cord segmentation - A-P somite patterning. The New Encyclopedia of Neuroscience 8: 537-544. Edited by Larry Squire et al. Oxford: Academic Press.

M.F. Batista and K.E. Lewis (2008) Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Developmental Biology. 323: 88–97. doi:10.1016/j.ydbio.2008.08.009 . doi:10.1016/j.ydbio.2008.08.009.

M.F. Batista, J. Jacobstein and K.E. Lewis (2008) Zebrafish V2 cells develop into excitatory CiD and Notch signaling dependent inhibitory VeLD interneurons. Developmental Biology. 322: 263-275. doi:10.1016/j.ydbio.2008.07.015 . doi:10.1016/j.ydbio.2008.07.015. (Plus cover image).

K. Wotton, F. Weierud, S.Dietrich, and K.E. Lewis (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology 8:171.

G. Lupo, W.A. Harris, K.E. Lewis (2006) Mechanisms of ventral patterning in the vertebrate nervous system. Nature Reviews Neuroscience 7:103-114.

K.E. Lewis (2006) How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified. Philosophical Transactions of the Royal Society B: Biological Sciences 361(1465): 45-66.

K.E. Lewis, J. Bates & J.S. Eisen (2005) Regulation of iro3 expression in the zebrafish spinal cord. Developmental Dynamics 232:140-148.

C. Wolff, S. Roy, K.E. Lewis, H. Schauerte, G. Joerg-Rauch, A. Kirn, C. Weiler, R. Geisler, P. Haffter & P. W. Ingham (2004) iguana encodes a novel zinc finger protein with coiled-coil domains essential for Hedgehog signal transduction in the vertebrate embryo. Genes and Development 18: 1565-1576.

K.E. Lewis & J.S. Eisen (2004) Paraxial Mesoderm Specifies Zebrafish Primary Motoneuron Subtype Identity. Development 131: 891-902.

K.E. Lewis & J.S. Eisen (2003) From Cells to Circuits: Development of the Zebrafish Spinal Cord. Progress in Neurobiology 69 (6): 419-449.

K.E. Lewis & J.S. Eisen (2001) Hedgehog signaling is required for primary motoneuron induction in zebrafish. Development 128: 3485-3495.

Z.M. Varga, A. Amores, K.E. Lewis, Y.-L. Yan, J.H. Postlethwait, J.S. Eisen, M. Westerfield (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128: 3497-3509.

G. Drossopoulou, K.E. Lewis, J.J. Sanz-Ezquerro, C. Hofmann, A.P. McMahon and C. Tickle (2000) A new model for antero-posterior patterning of the limb involving sequential long and short range Shh signalling and Bmp signalling. Development 127: 1337-1348.

K.E. Lewis, J.P. Concordet and P.W. Ingham (1999) Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling. Developmental Biology 208: 14-29.

K.E. Lewis, P.D. Currie, S. Roy, H. Schauerte, P. Haffter, and P.W. Ingham (1999) Control of muscle cell-type specification in the zebrafish embryo by hedgehog signalling. Developmental Biology 216: 469-480.

K.E. Lewis, G. Drossopoulou, I.R. Paton, D.R. Morrice, K.E. Robertson, D.W. Burt, P.W. Ingham and C. Tickle (1999) Expression of ptc and gli genes in talpid3;suggests bifurcation in Shh Pathway. Development 126: 2297-2407.

J.P. Concordet, K.E. Lewis, L. Goodrich, R. Johnson, M. Scott and P. Ingham (1996) Spatial Regulation of a Zebrafish Patched Homologue Reflects the Roles of Sonic Hedgehog and Protein Kinase A in Neural Tube and Somite Patterning. Development 122: 2835-2846.

J.D. Morrison, J.D. Corcoran and K.E. Lewis (1992) The Determination of Particle Size Distributions in Small-Angle Scattering using the Maximum-Entropy Method. J. Appl. Cryst. 25: 504-513.

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