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Katharine (Kate) Lewis

Katharine (Kate) Lewis

Associate Professor
Department of Biology

262 Life Sciences Complex

Research Interests

Specification and patterning of spinal cord interneurons; Formation of functional neuronal circuitry; Evolution of spinal cord patterning and function; Dorsal-ventral neural tube patterning; zebrafish development.


  • Postdoc, University of Oregon (1999-2003)
  • Ph.D., University College London (1994-1998)
  • Kennedy Memorial Scholar, Harvard University (1993-1994)
  • B.A. (Honors), Cambridge University (1990-1993)

Previous Academic Positions

Royal Society University Research Fellow, University of Cambridge 2004-2010

Selected Publications

  • S. England, P. Campbell, S. Banerjee, A. Swanson, K. E. Lewis (2017) Identification and expression analysis of the complete family of zebrafish pkd genes.Frontiers in Cell and Developmental Biology 5:5 doi: 10.3389/fcell.2017.00005
  • W. C. Hilinski; J. R. Bostrom; S. J. England; J. L. Juárez-Morales; S. de Jager; O. Armant; J. Legradi; U. Strähle; B. A. Link; K. E. Lewis (2016) Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Development. 11:16 DOI: 10.1186/s13064-016-0070-1. vJ.
  • L. Juarez-Morales, C. Schulte, S. A. Pezoa, G. K. Vallejo, W. Hilinski, S. England, S. de Jager and K. E. Lewis (2016) Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2 independent mechanism. Neural Development. 11: 5 DOI: 10.1186/s13064-016-0059-9.
  • A.Thélie, S. Desiderio, J. Hanotel, I. Quigley, B. Van Driessche, A. Rodari, M. D. Borromeo, S. Kricha, F. Lahaye, J. Croce, G. Cerda-Moya, J. O. Fernandez, B. Bolle, K. E. Lewis, M. Sander, A. Pierani, M. Schubert, J. E. Johnson, C. R. Kintner, T. Pieler, C. Van Lint, K. A. Henningfeld, E. J. Bellefroid, and C. V. Campenhout (2015) Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Development:142:3416-3428.
  • S. England, Hilinski, W., de Jager, S., Andrzejczuk, L. , Campbell, P., Chowdhury, T. , Demby, C. , Fancher, W. , Gong, Y. , Lin, C. , Machikas, A., Rodriguez-Larrain, G. , Roman Rivera, V. and Lewis, K. E. (2014) Identifying Transcription Factors expressed by Ventral Spinal Cord Interneurons. ZFIN on-line publication.
  • S. England, M. F. Batista, J. K. Mich, J. K. Chen and K. E. Lewis (2011) Roles of Hedgehog Pathway Components and Retinoic Acid Signalling in Specifying Zebrafish Ventral Spinal Cord Neurons. Development 138: 5121-5134.
  • D. K. Goode, H. A. Callaway, G. Cerda, K. E. Lewis and G. Elgar (2011) Minor change, major difference: divergent functions of highly conserved cis-regulatory elements subsequent to whole genome duplication events. Development 138: 879-884.
  • C. J. Schulte, C. Allen, S. England, J. Juárez-Morales and K. E. Lewis (2011) Evx1 is required for joint formation in zebrafish fin dermoskeleton. Developmental Dynamics 240: 1240-1248.
  • Cerda, G.A., Hargrave, M., and Lewis, K.E. (2009) RNA profiling of FAC-sorted neurons from the developing zebrafish spinal cord. Dev. Dyn. 238(1):150-161.
  • Wotton,K., Weierud F., Dietrich, S. and Lewis, K. E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology 8:171.
  • Batista, M.F., and Lewis, K.E. (2008) Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Dev. Biol. 323(1):88-97.
  • Batista, M.F., Jacobstein, J., and Lewis, K.E. (2008) Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. Dev. Biol.. 322(2):263-275.
  • Lupo,G., Harris,W.A. and Lewis, K.E. (2006) Mechanisms of ventral patterning in the vertebrate nervous system. Nature Reviews Neuroscience. 7:103-114.
  • Lewis, K.E. (2006) How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified. Philos Trans R Soc Lond B Biol Sci.. 361(1465):45-66.