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Heidi Hehnly

Heidi Hehnly


Assistant Professor
Department of Biology

hhehnly@syr.edu

236 Life Sciences Complex
315.443.2159


Research Interests

Our research interests include understanding the interface between cytoskeletal dynamics and membrane transport and defining how they co-regulate one another to control essential cellular processes such as cell division, fate, and polarity. 

Education

  • Visiting Scientist, University of Washington, Seattle (2014-15)
  • Postdoc, University of Massachusetts Medical School, Worcester Mass (2010-14)
  • Ph.D., University of Iowa, Iowa City IA (2003-2009)
  • B.S., University of Rochester, Rochester NY (1999-2003)

Previous Academic Appointments

  • Assistant Professor, SUNY Upstate Medical College, Syracuse, NY (2015-2018)

Selected Publications

  • Dao TP, Kolaitis RM, Kim HJ, O'Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA. Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions. Molecular Cell. 2018. Read article.
  • Colicino EG, Garrastegui AM, Freshour J, Santra P, Post DE, Kotula L, Hehnly H. Gravin regulates centrosome function through PLK1. Molecular Biology of the Cell. 2018. Read article.
  • Taneja N, Fenix AM, Rathbun L, Millis BA, Tyska MJ, Hehnly H, Burnette DT. Focal adhesions control cleavage furrow shape and spindle tilt during mitosis. Scientific Reports 2016. Read article.
  • Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release. Developmental Cell 2016. Read article.
  • Hung H, Hehnly H¥, Doxsey S¥. The mother centriole protein, cenexin, modulates symmetric lumen formation through spindle orientation. Current Biology 2016 (¥) depicts co-corresponding author. Read article.
  • Hehnly H*, Canton D*, Bucko P, Langeberg LK, Ogier L, Gelman I, Santana LF, Wordeman L, Scott JD. An Aurora A-Plk1 kinase scaffold depleted in testicular seminomas impacts mitotic spindle orientation in germline stem cells. eLIFE. 2015 depicts co-first authorship. Read article.
  • Elisa de Souza E, Hehnly H, Perez AM, Vaz Meirelles G, Costa Smetana JH, Doxsey S, Kobarg J., Human Nek7-interactor RGS2 is required for mitotic spindle organization. Cell Cycle. 2015 Feb 9:0. [Epub ahead of print] PMID: 25664600. Read article.
  • Chen CT*, Hehnly H*, Yu Q*, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, Doxsey S. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Current Biology. 2014 2014 Oct 6;24(19):2327-34. PMID: 25220058 depicts co-first authorship *Current Biology Commentary titled Pericentrin: critical for spindle orientation.”. Read article.
  • Hehnly H and Doxsey S, Rab11 endosomes contribute to mitotic spindle organization and orientation. Developmental Cell. 2014 Mar 10;28(5):497-507. PMID: 24561039 *Awarded Cover Image. *Developmental Cell Commentary titled “Spindlegate: the biological consequences of disrupting traffic.”. Read article.
  • Hehnly H, Chen CT, Powers C, Lui HL, and Doxsey S, The Centrosome regulates the Rab11-dependent recycling endosome pathway at appendages of the mother centriole. Current Biology. 2012 Oct 23; 22(20):1944-50. PMID: 22981775 *Featured in Faculty 1000 *Featured in Nature Reviews Molecular Cell Biology. Read article.
  • Hehnly H, Xu W, Chen J, and Stamnes M (2010) Cdc42 regulates microtubule-dependent Golgi positioning. Traffic. 11(8): 1067-78; PMID: 20525016 *Awarded Cover Image. Read article.
  • Hehnly H, Longhini K, Chen J, and Stamnes M (2009) Retrograde Shiga toxin trafficking is regulated by ARHGAP21 and Cdc42. Molecular Biology of the Cell. 20(20):4303-12 PMID: 19692570. Read article.
  • Hehnly H, Sheff D, Stamnes M (2006) Shiga toxin facilitates its retrograde transport by modifying microtubule dynamics. Molecular Biology of the Cell. 17(10): p.4379-89 PMID: 16885418. Read article.